SCIENCE & RESEARCH
The science behind the formula
AB-Free Kava
Enriches the six major kavalactones, which are responsible for kava’s relaxing property (1) and demonstrate the potential to prevent cancer (5, 13, 14) and suppress inflammation (15) in pre-clinical animal models.
Completely removes flavokavains A and B (5), the chemicals likely contributing to the purported hepatotoxic risk associated with kava use in the late 1990s.
Results in four clinical trials (NCT03843502, NCT04565145, NCT05381025 and NCT05081882) revealed no signs of liver stress at the recommended dose and regimen for AB-Free Kava usage (16, 17).
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Flavokavains A & B
Not responsible for kava’s relaxing property nor cancer preventive activity (1–5).
The most cytotoxic compounds in kava that kill a wide range of cells (6, 7).
Contain a reactive functional group that can trap glutathione (8), which may compromise the liver to hepatotoxic challenges.
Induce liver toxicity in pre-clinical animal models alone, and enhance the hepatotoxicity of acetaminophen (8, 9).
Non-noble kava cultivars (not recommended for human use), such as “Tudei” cultivars, contain 4 times more flavokavains A and B relative to noble kava cultivars (10, 11).
Six Major Kavalactones
Enriches the six major kavalactones, which are responsible for kava’s relaxing property (1) and demonstrate the potential to prevent cancer (5, 13, 14) and suppress inflammation (15) in pre-clinical animal models.
Bell-Shaped Health Profile
AB-Free Kava to restore homeostasis and enhance resilience. More is not always better, and just right — the bell-shaped health profiles.
Noble Cultivars
Non-noble kava cultivars (not recommended for human use), such as “Tudei” cultivars, contain 4 times more flavokavains A and B relative to noble kava cultivars traditionally used for kava drink preparations (10, 11).